Supportive Clinical Studies

Research supporting the ingredients and formulation of Deep Support Drops

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  3. GAG replenishment therapy for bladder pain syndrome/interstitial cystitis - PubMed, accessed January 20, 2026, https://pubmed.ncbi.nlm.nih.gov/30592544/
  4. Exploring the anti-inflammatory effects of phytochemicals in attenuating interstitial cystitis-a literature review - Frontiers, accessed January 20, 2026, https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1483548/full
  5. Uroprotective and pain-relieving effect of dietary supplementation with micronized palmitoyl-glucosamine and hesperidin in a chronic model of cyclophosphamide-induced cystitis - PubMed Central, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC10797840/
  6. Interstitial Cystitis and Bladder Pain Syndrome - Life Extension, accessed January 20, 2026, https://www.lifeextension.com/protocols/kidney-urinary/interstitial-cystitis-and-bladder-pain-syndrome
  7. The gut-kidney axis in chronic kidney disease: mechanisms, microbial metabolites, and microbiome-targeted therapeutics - Frontiers, accessed January 20, 2026, https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1675458/full
  8. The influence of gut microbiota on the gut-brain-kidney axis and its implications for chronic kidney disease - PMC - PubMed Central, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC12283296/
  9. Palmitoylethanolamide and Related ALIAmides for Small Animal Health: State of the Art, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC9496254/
  10. Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application Prospects - PMC, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC12358156/
  11. (PDF) Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application Prospects, accessed January 20, 2026, https://www.researchgate.net/publication/394452452_Palmitoylethanolamide_in_the_Treatment_of_Pain_and_Its_Clinical_Application_Prospects
  12. PEA Reduces Pelvic Pain in IC, Vulvodynia, Endometriosis, Prostatitis & Cramps, accessed January 20, 2026, https://www.icnetwork.org/pea-reduces-pelvic-pain-in-ic-vulvodynia-endometriosis-prostatitis-now-menstrual-cramping/
  13. Application of decellularized tilapia skin in rabbit urethral reconstruction: an experimental study - Translational Andrology and Urology, accessed January 20, 2026, https://tau.amegroups.org/article/view/135026/html
  14. Preparation of Enzyme-Soluble Swim Bladder Collagen from Sea Eel (Muraenesox cinereus) and Evaluation Its Wound Healing Capacity - PMC - NIH, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC10608547/
  15. Development of a unique crosslinked glycosaminoglycan for soft tissue repair: Treatment of interstitial cystitis/bladder pain syndrome - Research journals - PLOS, accessed January 20, 2026, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0317790
  16. Hyaluronic acid: Function and location in the urothelial barrier for bladder pain syndrome/interstitial cystitis, an in vitro study - PubMed, accessed January 20, 2026, https://pubmed.ncbi.nlm.nih.gov/40009603/
  17. Oral Glutamine Attenuates Cyclophosphamide-Induced Oxidative Stress in the Bladder but Does Not Prevent Hemorrhagic Cystitis in Rats - PMC - NIH, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC3724431/
  18. Protective effects of L-glutamine on the bladder wall of rats submitted to pelvic radiation, accessed January 20, 2026, https://www.researchgate.net/publication/235880042_Protective_effects_of_L-glutamine_on_the_bladder_wall_of_rats_submitted_to_pelvic_radiation
  19. Grass Fed Beef Liver Is the Best Source of Vitamin A - Acabonac Farms, accessed January 20, 2026, https://www.acabonacfarms.com/blogs/in-the-kitchen/grass-fed-beef-liver-is-the-best-source-of-vitamin-a
  20. Why Beef Organs Could Boost Your Brain and Muscles - Verywell Health, accessed January 20, 2026, https://www.verywellhealth.com/beef-organ-supplement-11710185
  21. Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology - PubMed Central, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC4137549/
  22. Antispasmodic activity and mechanism of action of polyherbal formulation DCD-684 on rabbit jejunum - ResearchGate, accessed January 20, 2026, https://www.researchgate.net/publication/353349318_Antispasmodic_activity_and_mechanism_of_action_of_polyherbal_formulation_DCD-684_on_rabbit_jejunum
  23. Fennel Tea Has a Region-Specific Effect on the Motility of the Stomach - PubMed Central, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC12623265/
  24. A Review on Herbal Antispasmodics, accessed January 20, 2026, https://www.ijpsjournal.com/article/A+Review+on+Herbal+Antispasmodics
  25. Spasmolytic Effects of Medicinal Plants - A Review, accessed January 20, 2026, https://ijpsjournal.com/article/Spasmolytic+Effects+of+Medicinal+Plants++A+Review
  26. Medicinal plants and natural products for treating overactive bladder - PMC, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC10967063/
  27. Study Details | NCT05348239 | Chlorophyllin Tablets for Urinary Bleeding Following Radiation Therapy for Cancers of Pelvic Organs | ClinicalTrials.gov, accessed January 20, 2026, https://www.clinicaltrials.gov/study/NCT05348239
  28. Preclinical evaluation of sodium copper chlorophyllin: safety, pharmacokinetics, and therapeutic potential in breast cancer chemotherapy and cyclophosphamide-induced bladder toxicity, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC12511210/
  29. (PDF) Preclinical evaluation of sodium copper chlorophyllin: safety, pharmacokinetics, and therapeutic potential in breast cancer chemotherapy and cyclophosphamide-induced bladder toxicity - ResearchGate, accessed January 20, 2026, https://www.researchgate.net/publication/391152278
  30. Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients | Request PDF - ResearchGate, accessed January 20, 2026, https://www.researchgate.net/publication/8656862
  31. The Efficiency of Chlorella vulgaris in Heavy Metal Removal: A Comparative Study of Mono- and Multi-Component Metal Systems - MDPI, accessed January 20, 2026, https://www.mdpi.com/2571-8797/7/2/35
  32. Effect of Chlorella vulgaris intake on cadmium detoxification in rats fed cadmium - PMC - NIH, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC2788181/
  33. Chlorella vulgaris Supplementation Attenuates Lead Accumulation, Oxidative Stress, and Memory Impairment in Rats - PubMed Central, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC12031184/
  34. Laminaria japonica polysaccharide protects against liver and kidney injury in diabetes mellitus through the AhR/CD36 pathway - PubMed, accessed January 20, 2026, https://pubmed.ncbi.nlm.nih.gov/39902919/
  35. Fucoidan Oligosaccharide Supplementation Relieved Kidney Injury and Modulated Intestinal Homeostasis in D-Galactose-Exposed Rats - MDPI, accessed January 20, 2026, https://www.mdpi.com/2072-6643/17/2/325
  36. Comparative Study of Fucoidan from Saccharina japonica and Its Depolymerized Fragment on Adriamycin-Induced Nephrotic Syndrome in Rats - MDPI, accessed January 20, 2026, https://www.mdpi.com/1660-3397/18/3/137
  37. Assessment of the state of synergies between the structural and functional characteristics of the kidneys and liver during external use of a seaweed product Laminaria algae - ResearchGate, accessed January 20, 2026, https://www.researchgate.net/publication/378286247
  38. Dietary flax oil rich in alpha-linolenic acid reduces renal disease and oxylipin abnormalities, including formation of docosahexaenoic acid derived oxylipins in the CD1-pcy/pcy mouse model of nephronophthisis - ResearchGate, accessed January 20, 2026, https://www.researchgate.net/publication/269713085
  39. Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation | Applied and Environmental Microbiology - ASM Journals, accessed January 20, 2026, https://journals.asm.org/doi/10.1128/aem.03044-15
  40. Substances released from probiotic Lactobacillus rhamnosus GR-1 potentiate NF-kB activity in Escherichia coli-stimulated urinary bladder cells - Oxford Academic, accessed January 20, 2026, https://academic.oup.com/femspd/article/66/2/147/495938
  41. Lactobacillus rhamnosus GR-1 | Database - Optibac Probiotics, accessed January 20, 2026, https://www.optibacprobiotics.com/professionals/probiotics-database/lactobacillus/lactobacillus-rhamnosus/lactobacillus-rhamnosus-gr-1
  42. Antimicrobial Activity of Intraurethrally Administered Probiotic Lactobacillus casei in a Murine Model of Escherichia coli Urinary Tract Infection - ASM Journals, accessed January 20, 2026, https://journals.asm.org/doi/10.1128/aac.45.6.1751-1760.2001
  43. Lactiplantibacillus plantarum Reduced Renal Calcium Oxalate Stones by Regulating Arginine Metabolism in Gut Microbiota - Frontiers, accessed January 20, 2026, https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.743097/full
  44. Screening of oxalate-degrading probiotics and preventive effect of Lactiplantibacillus plantarum AR1089 on kidney stones - PubMed, accessed January 20, 2026, https://pubmed.ncbi.nlm.nih.gov/39300803
  45. Lactiplantibacillus plantarum Reduced Renal Calcium Oxalate Stones by Regulating Arginine Metabolism in Gut Microbiota - PMC - NIH, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC8498331/
  46. Oxalate-Degrading Activity in Bifidobacterium animalis subsp. lactis: Impact of Acidic Conditions on the Transcriptional Levels of the Oxalyl Coenzyme A (CoA) Decarboxylase and Formyl-CoA Transferase Genes - PMC - PubMed Central, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC2918965/
  47. Oxalate-degrading activity of Bifidobacterium strains | Download Table - ResearchGate, accessed January 20, 2026, https://www.researchgate.net/figure/Oxalate-degrading-activity-of-Bifidobacterium-strains_tbl1_8368581
  48. A specifically designed multi-biotic reduces uremic toxin generation and improves kidney function, accessed January 20, 2026, https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2531202
  49. Effect of the Gut Microbiome on the reduction of uremic toxins in patients with chronic kidney disease: A systematic review & Network meta-analysis | medRxiv, accessed January 20, 2026, https://www.medrxiv.org/content/10.1101/2025.02.21.25322662v1
  50. Preventive Effects of Lactobacillus Mixture against Chronic Kidney Disease Progression through Enhancement of Beneficial Bacteria and Downregulation of Gut-Derived Uremic Toxins - PubMed, accessed January 20, 2026, https://pubmed.ncbi.nlm.nih.gov/34170659/
  51. Efficacy and Mechanism of the Action of Live and Heat-Killed Bacillus coagulans BC198 as Potential Probiotic in Ameliorating Dextran Sulfate Sodium-Induced Colitis in Mice - PMC - NIH, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC10918820/
  52. Bacillus coagulans TL3 Inhibits LPS-Induced Caecum Damage in Rat by Regulating the TLR4/MyD88/NF-kB and Nrf2 Signal Pathways and Modulating Intestinal Microflora - PMC - NIH, accessed January 20, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC8843965/
  53. The Bifidobacterium breve bacterium - Super Synbiotics, accessed January 20, 2026, https://en.supersynbiotics.se/maghalsa/gut-flora/the-bifidobacterium-breve-bacterium/
  54. Dose-Dependent Anti-Inflammatory Effects of Live and Heat-Treated Ligilactobacillus salivarius and Bifidobacterium breve via NF-kB and COX-2 Modulation in an In Vitro Model of Airway Inflammation - MDPI, accessed January 20, 2026, https://www.mdpi.com/2072-6643/17/15/2504
  55. A systematic review and meta-analysis of clinical trials on the effects of glutamine supplementation on gut permeability in adults - PubMed, accessed January 20, 2026, https://pubmed.ncbi.nlm.nih.gov/39397201/